Next-generation sequencing (NGS) is a tool that is used to extract and analyze molecular information and has been able to explore the human genome in an unprecedented manner. The next-generation sequencing technology is used in basic human disease research and can be used in routine research as well.
Furthermore, the key reason to use targeted sequencing is that it is more cost-effective as compared to whole genome sequencing. This also enables deeper result analysis as compared to whole genome sequencing and other sequencing approaches. Deeper sequencing and higher depth of coverage with targeted sequencing can help avoid false interpretations of the sequencing data. This sensitivity allows targeted sequencing to provide a huge advantage of variant calling in cancer research, identification of disease mutations, gene expression studies, and signal gene disorders. Sequencing specific regions also allows one to discover causative genes and rare diseases. This focused approach allows the possibility of the use of targeted sequencing in targeted therapy applications and personalized medicine efforts.
Targeted Sequencing Market is projected to reach $10,976.1 million by 2032 from $3,198.8 million in 2022, growing at a CAGR of 13.12% during the forecast period 2022-2032. The growth in the global targeted sequencing market is expected to be driven by the increased use of targeted sequencing in clinical laboratories and diagnostic applications, especially in cancer research.
Market Lifecycle Stage
Targeted sequencing is a cost-effective and rapid way to detect novel and known variants in selected genetic or genomic regions. There are several different methods of DNA/RNA sequencing depending on the scale of the region being sequenced. Next-generation sequencing (NGS) is the most used method for targeted sequencing, which offers good scalability, speed, and resolution to evaluate the targeted regions of interest. Other methods include sanger sequencing and CRISPR.
The major advantage of targeted sequencing as compared to whole genome sequencing is the smaller and more manageable data sets created, which are significantly easier to analyze. Targeted next-generation sequencing focuses on specific genomic areas of interest, which is ideal for examining specific pathways or targeted resequencing. Furthermore, it is more rapid and cost-effective as compared to whole genome sequencing and allows deeper sequencing. This is a powerful and especially sensitive method of identifying gene mutations and variants, including rare variants.
Market Overview
Market Footprint and Growth Potential
Targeted sequencing can have many specific uses in clinical, research, pharmaceutical, etc. fields and various products like instruments, bioinformatics, consumables, and services. Till now, targeted sequencing is most widely done in research settings, which include academic and research institutions, but it is slowly transferring to diagnostic and clinical applications. Targeted sequencing is also increasingly being used by pharmaceutical and biotech companies that are working on a number of large-scale genome sequencing projects that are helping in genomics drug development programs. However, the complication being faced by pharmaceutical companies in the use of targeted sequencing is the struggle to find acceptance from stakeholders and build a commercially viable business model. This problem is mainly due to the limited clinical applications of targeted sequencing currently available.
Key Companies Profiled
- Agilent Technologies, Inc.
• Azenta US, Inc. (GENEWIZ)
• BGI Group (MGI Tech Co., Ltd.)
• CD Genomics
• Daicel Corporation (Daicel Arbor Biosciences)
• Danaher. (Integrated DNA Technologies, Inc.)
• F. Hoffmann-La Roche Ltd
• Illumina, Inc.
• LGC Limited (LGC Biosearch Technologies)
• PacBio.
• PerkinElmer Inc.
• Psomagen
• QIAGEN N.V.
• Takara Bio Inc.
• Tecan Trading AG
• Thermo Fisher Scientific Inc.
• Twist Bioscience.
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Key Questions Answered in the Report
▪ How is the targeted sequencing market revolutionizing the NGS sequencing industry?
▪ What are the major market drivers, challenges, and opportunities in the global targeted sequencing market?
▪ What are the underlying structures resulting in the emerging trends within the targeted sequencing market?
▪ How did the COVID-19 pandemic impact the global targeted sequencing market?
▪ What are the key development strategies that are being implemented by major players to sustain themselves in the market?
▪ What are the key regulatory implications in developed and developing regions pertaining to the use of targeted sequencing applications?
▪ What are the potential entry barriers that are expected to be faced by the companies willing to enter a particular region in the market?
▪ What will be the growth rate of the global targeted sequencing market during the forecast period 2022- 2032?
▪ How is each segment of the market expected to grow during the forecast period 2022-2032, and what revenue is anticipated to be generated by each of the segments?
The following are the segments:
o Product Type (Services, Kits/ Panels and Assays, Instruments, and Other Product Types)
o Target Enrichment Method (Amplicon Sequencing, Hybridization Capture, and Other Target Enrichment Methods)
o Type of Target Capture (Targeted DNA Sequencing, Targeted RNA Sequencing, and Other Types of Target Capture)
o Application (Oncology, Infectious Diseases, Cardiovascular Diseases, Reproductive Health, Rare Diseases, Neurological Disorders, Hereditary Diseases, and Other End Users)
o Region (North America, Europe, Asia-Pacific, Latin America, and Rest-of-the-World)
▪ What are the growth opportunities for the targeted sequencing companies in the region of their operation?
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