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Heparin magnetic particles are designed with heparin on the surface, which have the characteristics of rapid magnetic response, high heparin density, high physical and chemical stability, and so on. Heparin (hep) is a highly charged polyanionic glycosaminoglycan, which is widely used as a clinical anticoagulant and consists of a complex mixture of linear anionic polysaccharides with an average molecular weight of 16 kDa.